Description
Propylene glycol has good solubility, less toxicity and irritation, and is widely used as injections (such as intramuscular injections, intravenous injections) and non-injectable pharmaceutical preparations (such as oral liquids, ophthalmic preparations, ear preparations, dental preparations, rectovaginal preparations) It is a better solvent than glycerin and can dissolve many substances such as corticosteroids (sex hormones), chloramphenicol, sulfonamides, barbituric acid Salt, reserpine, quinidine, dehydrocorticosterone acetate, fumarate sulfate, nitrogen mustard hydrochloride, vitamin A, vitamin D, many volatile oils, most alkaloids, and many local anesthetics. Propylene glycol is similar to ethanol as a bacteriostatic agent, and its efficacy in inhibiting mold is similar to that of glycerin, but slightly lower than that of ethanol. Propylene glycol is commonly used as a plasticizer for aqueous film coatings. The same amount of mixed solution with water can delay the hydrolysis of some drugs and increase the stability of the preparation product. 15%~30% propylene glycol solution and semi-solid preparation can be used as antibacterial preservatives, about 15% propylene glycol topical preparation can be used as moisturizing agent, 10%~30% propylene glycol aerosol solvent, 10%~25% % propylene glycol oral solution, 10% to 60% of injection preparations, and 5% to 80% of topical preparations should be used as solvents and co-solvents.
